Generic
Carboplatin
(KAR-boh-pla-tin)
Brands
Paraplatin®
Additional Resources
Carboplatin (Paraplatin®) is used to treat advanced ovarian cancer but may be used for other treatments.
Our Medication Sheet
This sheet is available to download as an Adobe PDF.
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Page 1 INTRAVENOUS CANCER TREATMENT EDUCATION CARBOPLATIN Name of the regimen and cancer drugs • Carboplatin (KAR boh pla tin): Paraplatin® Common uses • Carboplatin is used to treat advanced ovarian cancer but may be used for other treatments. Treatment schedule Your treatment will be given into your vein through an intravenous (IV) line. This may be into a short, fl exible temporary catheter in your arm, or through a central venous catheter. A central venous catheter, or central line is a long, fl exible IV tube that empties into a very large vein next to the heart. Talk with your care team to see which will be best for you and your treatment. Each carboplatin treatment is repeated every 21 days (3 weeks). This is known as one cycle. Your treatment may be given for a set number of cycles, or it will keep going until the drug stops working or you have side eff ects which stop you from continuing treatment. Carboplatin IV is given on Day 1. Drug DAY 1 2 3 4 5 6 7 8 ... 21 Cycle 2 Day 1 Carboplatin X X Page 2 Other medications Other medications may be ordered for you to prevent or treat certain side eff ects. These include: Possible drug interactions Carboplatin may interact with other drugs you are taking. Please inform your care providers of all prescription medicine, over-the-counter medications, vitamins, and herbal products that you take. Talk with your care provider or pharmacist before taking new medications, supplements, or receiving any vaccines. Anti-nausea medications You will receive medications in the clinic to prevent nausea just before your cancer treatment. You may also get prescriptions for other medications to take at home, as below: ____________________________________________________________________ Medications to prevent side eff ects (when nausea premedication is not necessary) You will receive your medications in the clinic to prevent side eff ects just before your cancer treatment. You may get prescriptions for other medications to take at home, as below: Instructions: Growth Factors Growth factors, like fi lgrastim, pegfi lgrastim, and others, are medications used to treat neutropenia and prevent infections. Neutropenia is a condition where there are lower-than-normal white blood cells caused by some type of chemotherapy. Growth factors help the bone marrow to make more white blood cells. Page 3 Common Side Eff ects Common side eff ects that have been known to happen in patients receiving carboplatin are listed in the left side of this table. In some instances, the side eff ects may be reported less often but are still important to discuss. This table does not list all the known side eff ects for this therapy, only the ones that are experienced most often. Not every patient experiences every known side eff ect of a drug; even if you are taking the same drug as another patient, you may experience diff erent side eff ects. Options to help manage any side eff ects that do occur are included on the right side of this table. These should be discussed with your care provider. If you experience any side eff ect you cannot manage or that is not listed here, contact your care provider. Possible Side Eff ect Management Decreased white blood cells (WBCs) and increased risk for infection Your WBCs should be monitored by a simple blood test. When your WBCs are low, you are at a greater risk of having an infection. Take the following precautions to protect yourself from infection. • Wash your hands often, especially before eating and after using the bathroom. • Avoid crowds and people with fevers, fl u, or other infection. • Bathe often for good personal hygiene. Contact your care team if you experience any signs or symptoms of an infection such as: Fever (temperature more than 100.4°F or 38°C) • Chills • Sore throat • Burning when peeing • Tiredness that is worse than normal • A sore that becomes red, is draining, or does not heal. Check with your care team before taking any medicine for a fever or chills. Decreased platelet count and increased risk of bleeding Your platelets should be monitored by a simple blood test. When they are low, you may bruise or bleed more easily than usual. • Use caution to avoid bruises, cuts, or burns. • Blow your nose gently and do not pick your nose • Brush your teeth gently with a soft toothbrush and maintain good oral hygiene • When shaving use an electric razor instead of razor blades • Use a nail fi le instead of a nail clippers Call your care team if you have bleeding that won’t stop. Examples include: • A bloody nose that bleeds for more than 5 minutes despite pressure • A cut that continues to ooze despite pressure • Gums that bleed a lot when you fl oss or brush Continued on the next page Page 4 (continued) Seek medical help right away if you have any severe headaches, blood in your urine or stool, coughing up blood, or bleeding that you cannot stop or lasts a long time. You may need to take a break or “hold” your medication for medical or dental procedures. Talk to your care team or dentist before any scheduled procedures. Decreased hemoglobin, part of the red blood cells that carry iron and oxygen Your hemoglobin should be checked by a simple blood test. When your hemoglobin is low, you may notice that you get tired or fatigued more easily. • Try to get 7 to 8 hours of sleep per night • Avoid operating heavy machinery if you feel too tired • Find a balance between “work” and “rest” • Stay as active as possible, but know that it is okay to rest as needed, too • You might notice that you are more pale than usual Let your care team know right away if you have: • Shortness of breath • Dizziness • Fast or abnormal heartbeat Changes in electrolytes and other laboratory values: • Low sodium levels • Low magnesium levels • Low calcium levels • Low potassium Changes in some lab values may occur and will be monitored by a simple blood test. • You may not feel any symptoms if the changes are mild and they usually are not a sign of a serious problem. • More severe changes may occur which can be a sign of a serious problem. Notify your care team if you have any of the following: • Chest discomfort. • Weakness or fatigue • New aches and pains • Headaches • Swelling of your legs or feet • Red or brown colored urine Page 5 Changes in liver function Your liver function will be checked every so often by a simple blood test. Contact your care team if you notice any of the following. • Yellowing of the skin or whites of your eyes • Dark or brown urine • Bleeding or bruising Nausea or vomiting • Take all medications as prescribed to help prevent and lessen symptoms of nausea and vomiting • Eat and drink slowly • Drink 8-10 (8-ounce) glasses of water and/or fl uid (soup or broth) each day unless your care team has instructed you to limit your fl uid intake • Eat small, frequent meals throughout the day rather than a few large meals • Eat bland foods; avoid spicy, fried, and greasy foods Diarrhea (loose and/ or urgent bowel movements) Monitor how many bowel movements you have each day. • Drink 8-10 (8-ounce) glasses of water or fl uid each day unless your care team has asked you to limit your fl uid intake. • Eat small, frequent meals throughout the day rather than a few large meals. • Eat bland, low-fi ber foods (such as bananas, applesauce, potatoes, chicken, rice, and toast). • Avoid high fi ber foods, such as raw vegetables and fruits and whole grains. • Avoid foods that cause gas, such as broccoli and beans. • Avoid foods with lactose, such as yogurt and milk. • Avoid spicy, fried, and greasy foods. Contact your care team if: • The number of bowel movements you have in a day increases by 4 or more • You feel dizzy or lightheaded • Your care team may recommend an over-the-counter medication or prescribe something to help keep it under control Page 6 Muscle or joint pain or weakness • Keep a diary of your pain including when and where the pain happens, what it feels like, and how long it lasts • Tell your care team if pain limits what you can do If the pain or weakness bothers you, ask your provider what you may use to help with this discomfort. Take only pain medication that has been prescribed or recommended by your care team. Hair loss (alopecia) • Your hair will likely grow back after treatment is over. • Some people choose to wear scarves, caps, or wigs. A short haircut prior to treatment may help with stress of hair loss. • Partial or complete hair loss is likely, usually 1-2 weeks after start of therapy. This hair loss can be all body hair. • Hair will grow back after treatment is completed, although the color and/or texture may be diff erent • It may take 3 to 6 months after therapy is completed to resume normal hair growth • Be sure to keep your head covered to protect it from the sun during the summer and cold during the winter. • If not covering your scalp during the summer months, be sure to use sunscreen when spending time outdoors. Pain • Keep a diary of your pain, including when and where the pain happens, what it feels • Tell your care team if pain interferes with your activity If the pain bothers you, ask your provider what you may use to help. Take only pain medication that has been prescribed or recommended by your care team. Page 7 Rare but serious side eff ects Bone marrow suppression is a decrease in the number of white blood cells, red blood cells and platelets that can be severe with carboplatin. Speak to your care team to know when you need to have laboratory tests done to monitor your blood cell counts. You also may need to take a break or “hold” your medication for medical or dental procedures. Severe allergic reactions are a rare but serious side eff ect of carboplatin. Seek medical attention right away if you notice diffi culty breathing, swelling of the mouth or tongue, or a serious rash. Carboplatin may cause numbness, pain, or burning in your hands or feet. Talk to your care team about ways to resolve this side eff ect. Carboplatin may cause hearing loss. Talk to your care team about monitoring for hearing loss or if you have any symptoms of hearing loss. Carboplatin may be harmful to your eyes. Be sure to inform your care team of any issue you have with your vision or pain in your eyes. Your provider may stop treatment with Carboplatin if your eyes are aff ected. If you experience ANY new, worsening, or uncontrolled side eff ects, call your care team immediately. ________________________________________________________________________ (INSTITUTIONAL CONTACT INFO) Page 8 Handling body fl uids and waste Some of the drugs you receive may be present in urine, stool, sweat, or vomit for many days after treatment. Many cancer drugs are toxic, your bodily waste may also be toxic and can be dangerous to come into contact with. Once you have started carboplatin, follow the instructions below for at least two days after your treatment. This is to keep you, your loved ones, and the environment as safe as possible. Pregnant women should avoid touching anything that may be soiled with body fl uids from the patient. Toilet and septic systems • You may use the same toilet, septic tank, and/or sewer that you usually use. If you have a low-fl ow toilet, close the lid and fl ush twice to ensure that all waste has been discarded. If the toilet or toilet seat becomes soiled with urine, stool, or vomit, clean the surface after every use before other people use the toliet. Wash hands with soap and water after using the toilet for at least 20 seconds. If you need a bedpan, be sure your caregiver knows to wear gloves to assist with cleanup and to wash the bedpan with soap and water every day. If you do not have good control of bladder or bowels, use a disposable pad with a plastic back, a diaper, or a sheet to absorb body waste. Wash any skin that has been exposed to body waste with soap and water. Linens or clothing that are soiled with body fl uids or body waste should be washed separately from other linens and clothing. If you do not have a washer, place the soiled linens in a plastic bag until they can be washed. Wash hands with soap and water after touching linens or clothing that may be soiled with body fl uids. Intimacy, sexual activity, contraception, and fertility This treatment may cause changes that can aff ect intimacy and sexuality, including desire and body image. Maintaining physical closeness and/or intimacy with loved ones can be continued during treatment. Holding hands, hugging, and kissing can be done safely. It is recommended that you talk to your care team about any restrictions or questions you may have. Some treatments can infl uence the ability to have children, also known as fertility. If you’re interested in preserving fertility, talk to your care team before treatment. Ask your healthcare provider to determine when it is safe to become pregnant after your treatment. Patients of reproductive ability should not become pregnant or get their partners pregnant while receiving carboplatin. Some of the drugs you receive may be present in semen and vaginal secretion for many days after treatment. You should use barrier devices, such as condoms, during sexual activity to limit exposure to body fl uids. Talk to your care team about birth control. Not all options may be right for your treatment or cancer. Eff ective contraception could include one or more of the following: barrier methods (e.g. condoms), hormone methods (e.g. birth control pills), or surgery. Tell your care team if you become pregnant or plan to breastfeed. Page 9 Additional resources Product Prescribing information link: http://labeling.pfi zer.com/ShowLabeling.aspx?id=4379 Additional instructions Updated – December 15, 2021 Important notice: The Association of Community Cancer Centers (ACCC), Hematology/Oncology Pharmacy Association (HOPA), National Community Oncology Dispensing Association, Inc. (NCODA), and Oncology Nursing Society (ONS) have collaborated in gathering information for and developing this patient education guide. This guide represents a brief summary of the therapy derived from information provided by the drug manufacturer and other resources. This guide does not cover all existing information related to the possible uses, directions, doses, precautions, warnings, interactions, adverse eff ects, or risks associated with this therapy and should not substitute for the advice of a qualifi ed healthcare professional. Provision of this guide is for informational purposes only and does not constitute or imply endorsement, recommendation, or favoring of this therapy by ACCC, HOPA, NCODA, or ONS, who assume no liability for and cannot ensure the accuracy of the information presented. The collaborators are not making any representations with respect to the medications whatsoever, and any and all decisions, with respect to such medications, are at the sole risk of the individual receiving therapy. All decisions related to receiving this therapy should be made with the guidance and under the direction of a qualifi ed healthcare professional. Permission: Intravenous Cancer Treatment Education (IVE) sheets are provided as a free educational resource for patients with cancer in need of concise, easy-to-understand information about intravenous cancer therapy. Healthcare providers are permitted to copy and distribute the sheets to patients as well as direct patients to the OCE website for information. However, commercial reproduction or reuse, as well as rebranding or reposting of any type, are strictly prohibited without permission of the copyright holder. Please email permission requests and licensing inquiries to This email address is being protected from spambots. You need JavaScript enabled to view it.. Copyright © 2021 by NCODA. All rights reserved.